Objectives: To update the WHO global and regional estimates of the pre
valence and incidence of syphilis, gonorrhoea, chlamydia, and trichomo
niasis. Methods: Prevalence estimates for syphilis, gonorrhoea, chlamy
dia, and trichomoniasis were generated for each of the nine UN regions
for males and females between the ages of 15 and 49 in 1995 based on
an extensive review of the published and unpublished medical literatur
e since 1985. Incidence estimates were based on the prevalence figures
and adjusted to take into account the estimated average duration of i
nfection for each disease in a particular region. The latter was assum
ed to depend upon a number of factors including the duration of infect
ion in the absence of treatment, the proportion of individuals who dev
elop symptoms, the proportion of individuals treated, and the appropri
ateness of treatment. Results: In 1995 there were over 333 million cas
es of the four major curable STDs in adults between the ages of 15 and
49-12 million cases of syphilis, 62 million cases of gonorrhoea, 89 m
illion cases of chlamydia, and 170 million cases of trichomoniasis. Ge
ographically, the vast majority of these cases were in the developing
world reflecting the global population distribution. Conclusions: STDs
are among the most common causes of illness in the world. Estimates o
f the global prevalence and incidence of these infections are limited
by quantity and quality of data available from the different regions o
f the world. Improving global STD estimates will require more well des
igned epidemiological studies on the prevalence and duration of infect
ion.