In the absence of aetiological tests for the diagnosis of individual s
exually transmitted diseases (STD), the syndromic approach has been de
veloped as an effective and appropriate case management strategy. Algo
rithms provide guidance to healthcare workers and ensure standardised
approaches to case management. The syndromic approach, utilising curre
ntly available algorithms, works well in the management of people with
symptomatic urethritis, genital ulcer disease, and vaginitis. Owing t
o the frequently asymptomatic nature of gonococcal and/or chlamydial c
ervicitis, and the lack of specific defining risk factors and/or signs
and symptoms, the syndromic approach performs less well in the identi
fication and management of women with cervicitis. The syndromic approa
ch can and should be adopted for the management of patients with ureth
ral discharge, genital ulceration, vaginal discharge, and cervical sig
ns. Further research is needed to improve the identification and manag
ement of cervical infections; to guide policy makers in selecting the
most appropriate disease control strategy; to improve utilisation of a
vailable and future tests; to develop affordable, rapid, and simple di
agnostic tests; and to develop STD vaccines.