COMPARISON BETWEEN THE EFFICACY AND TOLERABILITY OF OXERUTINS AND TROXERUTIN IN THE TREATMENT OF PATIENTS WITH CHRONIC VENOUS INSUFFICIENCY

Oxerutins ( Venoruton(R)) and troxerutin (CA S 7085-55-4) are both mix tures of O-(beta-hydroxyethyl)-rutosides used for the treatment of chr onic venous insufficiency. As di-O-(beta-hydroxyethyl)-rutosides and 7 -mono-O-(beta-hydroxyethyl)-rutoside were found to be more active with regard to free radical scavenging compared to tri-O-(beta-hydroxyethy l)-rutoside the aim of this study was to compare oxerutins and troxeru tin clinically. 12 female, post-menopausal patients with chronic venou s insufficiency grade II participated in this double-blind study with random allocation to the treatment groups. They received 900 mg/day ox erutins or troxerutin for 12 weeks and were observed for 4 further wee ks without treatment. Leg volumes (water displacement) and subjective symptoms (VAS, visual analogue scale) were evaluated before and follow ing 2, 4, 8, 12 and 16 weeks. Both treatments were active in reducing leg volumes and in ameliorating subjective symptoms (mean volume reduc tion -167 +/- 157 ml x week). Volume reduction totalled to - 261 +/- 1 54.2 ml x week for oxerutins and -73.2 +/- 97.1 ml x week for troxerut in. The difference is statistically significant (p = 0. 04). The findi ngs with subjective symptoms were in good accordance to the objective volume measurement. Oxerutins revealed a remarkable carry over effect.