Intrauterine growth retardation increases the risks to subsequent func
tioning among low birthweight children, but the quality of the caretak
ing environment may influence the impact of these risks. This prospect
ive report examined the consequences of intrauterine growth retardatio
n, neonatal medical risk, and environmental risk for attentional diffi
culties during early childhood. The developmental status of small-for-
gestational-age (SCA) children was within the normal range during infa
ncy but was significantly poorer than that of appropriate-for-gestatio
nal-age (AGA) children. Among SCA children, neonatal illness and prema
turity had differential influences on childhood attentional difficulti
es. Intrauterine growth retardation interacted with the quality of the
environment to influence the child's ability to sustain attention and
inhibit impulsive responses in a task situation. For both SGA and AGA
children, the effect of environmental risk was manifested in hyperact
ive behaviors in the home context.