PHYSIOLOGICAL CONTROLS OF ERYTHROMYCIN PRODUCTION BY SACCHAROPOLYSPORA-ERYTHRAEA ARE EXERTED AT LEAST IN PART AT THE LEVEL OF TRANSCRIPTION

Authors
REEVE LM BAUMBERG S
Citation
Lm. Reeve et S. Baumberg, PHYSIOLOGICAL CONTROLS OF ERYTHROMYCIN PRODUCTION BY SACCHAROPOLYSPORA-ERYTHRAEA ARE EXERTED AT LEAST IN PART AT THE LEVEL OF TRANSCRIPTION, Biotechnology letters, 20(6), 1998, pp. 585-589
Citations number
22
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Biotechnology letters → ACNP
ISSN journal
01415492
Volume
20
Issue
6
Year of publication
1998
Pages
585 - 589
Database
ISI
SICI code
0141-5492(1998)20:6<585:PCOEPB>2.0.ZU;2-B
Abstract
Erythromycin production by Saccharopolyspora erythraea is confined to the idiophase, derepressed by low initial glucose or phosphate concent ration, and repressed when ammonium was used as nitrogen source. The i diophase limitation and effects of low phosphate or ammonium correlate d with amounts of ery mRNA revealed by Northern blotting, indicating t hat they act at least partly at the transcriptional level.