ACCUMULATION OF LEAD IN TISSUES AFTER ITS ADMINISTRATION IN DRINKING-WATER TO LABORATORY RATS

Citation
O. Mestek et al., ACCUMULATION OF LEAD IN TISSUES AFTER ITS ADMINISTRATION IN DRINKING-WATER TO LABORATORY RATS, Physiologia bohemoslovaca, 47(3), 1998, pp. 197-202
Citations number
10
Categorie Soggetti
Physiology
Journal title
ISSN journal
03699463
Volume
47
Issue
3
Year of publication
1998
Pages
197 - 202
Database
ISI
SICI code
0369-9463(1998)47:3<197:AOLITA>2.0.ZU;2-7
Abstract
Lead administered to laboratory rats in drinking water (0.1-0.8%) as l ead acetate solution tends to accumulate in collagen-rich tissues such as tendons and the skin. The amount of lead deposited (and also zinc present in the tissue without its supplementation) correlates with the blood supply to the tissue investigated. The highest deposits of lead were observed in placenta and chorionic membranes, though here only a bout 60% are collagen-bound. No differences in the drinking habits of the animals were observed and also at lower concentrations of lead in the drinking water no dose dependence was revealed. However, at 0.8 % of lead in drinking water considerable accumulation of lead was observ ed in all tissues investigated.