O. Mestek et al., ACCUMULATION OF LEAD IN TISSUES AFTER ITS ADMINISTRATION IN DRINKING-WATER TO LABORATORY RATS, Physiologia bohemoslovaca, 47(3), 1998, pp. 197-202
Lead administered to laboratory rats in drinking water (0.1-0.8%) as l
ead acetate solution tends to accumulate in collagen-rich tissues such
as tendons and the skin. The amount of lead deposited (and also zinc
present in the tissue without its supplementation) correlates with the
blood supply to the tissue investigated. The highest deposits of lead
were observed in placenta and chorionic membranes, though here only a
bout 60% are collagen-bound. No differences in the drinking habits of
the animals were observed and also at lower concentrations of lead in
the drinking water no dose dependence was revealed. However, at 0.8 %
of lead in drinking water considerable accumulation of lead was observ
ed in all tissues investigated.