Methicillin-resistant Staphylococcus aureus (MRSA) has not been studie
d in child care centers. The prevalence of hlRSA colonization was dete
rmined at two centers with an index patient. Two (3%) of 61 children a
t center X had MRSA; strains from both children and the index illness
were pulsed-field gel electrophoresis type B, Nine (24%) of 40 childre
n at center Y had MRSA; strains from 5 children and the index illness
were type B, and strains from 4 children were type A. Ten of 11 coloni
zed children were in classes with 2- and 3-year-old children. Coloniza
tion with MRSA was not associated with health care contact by subjects
or by members of their households. MRSA in child day care centers ind
icates accelerated spread of MRSA in the community.