CELL-CYCLE DEPENDENCY OF PORPHYRIN UPTAKE IN A GLIOMA CELL-LINE

We used a two-color analysis system to assess the porphyrin uptake and DNA content in four established cell lines of glioma employing flow c ytometry (FCM). The FCM study revealed porphyrin uptake in all cells, regardless of the phase of the cell cycle they were in. However, those in the G0/G1 phase showed moderate uptake of porphyrin and those in t he G2/M phase showed a higher uptake. These results indicated the adva ntage of using porphyrin as the carrier of tumor targeting agents as a therapeutic strategy for malignant tumors. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.