Sb. Nelson et al., THE GNRH PROMOTER - TARGET OF TRANSCRIPTION FACTORS, HORMONES, AND SIGNALING PATHWAYS, Molecular and cellular endocrinology, 140(1-2), 1998, pp. 151-155
Gonadotropin-releasing hormone (GnRH) is essential for normal reproduc
tive maturation and function. We present a review of the known mechani
sms of hypothalamic GnRH transcriptional control through the conserved
GnRH promoter. Understanding this promoter region will allow us to co
mprehend better the complexities of the hypothalamic-pituitary-gonadal
axis. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.