Ps. Mehta et al., INCREASE IN BRAIN-STEM CYTOKINE MESSENGER-RNA LEVELS AS AN EARLY RESPONSE TO CHEMICAL-INDUCED MYELIN EDEMA, Journal of neuroimmunology, 88(1-2), 1998, pp. 154-164
This study examined the early response of pro-inflammatory and regulat
ory cytokines in the mouse brain following triethyltin (TET)-induced m
yelin injury characterized by edematous vacuolation. Following an acut
e intraperitoneal injection of triethyltin (TET) sulfate (3 mg/kg) to
17-day old CD1 mice, significant increases in brain stem TNF-alpha and
IL-1 alpha mRNA levels occurred at 6 and 24 h, respectively with elev
ations in TGF-beta 1 and MIP-1 alpha at 1 h. In the cortex, responses
were limited to elevations at 6 h in TNF-alpha, TGF-beta 1 and MIP-1 a
lpha. These data suggest that a chemokine/cytokine response can occur
with minimal alterations to the integrity of the myelin sheath and may
contribute to the initial signaling mechanisms associated with demyel
inating disorders. (C) 1998 Elsevier Science B.V. All rights reserved.