N. Onier et al., INVOLVEMENT OF T-LYMPHOCYTES IN CURATIVE EFFECT OF A NEW IMMUNOMODULATOR OM-163 ON RAT COLON-CANCER METASTASES, European journal of cancer, 29A(14), 1993, pp. 2003-2009
In a model of colon cancer in syngeneic rats, a new immunomodulator, O
M 163, induced the complete disappearance of peritoneal carcinomatosis
(nodules measuring 1-5 mm) in 41 out of 82 rats. Those results were c
onfirmed in a survival experiment in which 3 out of 10 treated rats di
ed free of tumour 10, 18 and 28 months after the tumour cell injection
while all the untreated control rats died of their tumours within 3 m
onths. OM 163 had a systemic effect, since injected intraperitoneally
it completely inhibited the growth of lung metastases in 13 out of 20
rats. The antitumour effect of OM 163 was also observed in two rat str
ains on original tumours. Lymphocyte infiltration was observed in the
tumours mainly constituted of CD4+ and CD8+ cells. The treatment had n
o effect in nude rats, confirming the involvement of T lymphocytes. Fu
rthermore, rats cured by OM 163 were protected against a second challe
nge of tumour cells and in a Winn's assay, splenocytes from cured rats
protected normal rats against tumour cells.