MULTICENTER EVALUATION OF PRAMIRACETAM FOR THE TREATMENT OF MEMORY IMPAIRMENT OF PROBABLE VASCULAR ORIGIN

This multicenter, open, noncomparative study involved 104 elderly pati ents with cognitive impairment of probable vascular origin. On the bas is of Mini-Mental State Examination score, patients were further chara cterized as having mild or moderate memory impairment. Pramiracetam wa s administered orally twice a day at 600 mg for 3 months. Patients wer e evaluated before treatment and after 30, 60, and 90 days by means of the Mini-Mental State, Information-Memory-Concentration, Figures Repe tition, and Rey's 15 Words tests. Pramiracetam proved to be safe and c linically effective in improving mental deterioration, with an order o f magnitude closely related to the severity of the memory disorder.