STUDIES ON THE ACETOGENINS OF FORMOSAN ANNONACEOUS PLANTS .2. CYTOTOXIC ACETOGENINS FROM ANNONA-RETICULATA

Using cytotoxicity as a guide to fractionation, one novel acetogenin, annoreticuin-9-one [3], and four known cytotoxic acetogenins, squamone [4], solamin [5), annomonicin [6], and rolliniastatin 2 M, were isola ted from active extracts of the leaves of the Formosan plant Annona re ticulata. Their structures were elucidated on the basis of uv, ir, H-1 -and C-13-nmr, and ms data of the natural compounds and their derivati ves.