Fasciolosis is recognised as a major problem in dairy cattle in Cajama
rca, Peru, The infection has an annual cycle, with the major period of
infection from January to March. A control programme, involving two d
oses of the fasciolicide triclabendazole aimed at reducing the passage
of Fasciola hepatica eggs on to the pasture, together with the use of
the molluscicide, niclosamide, was evaluated against traditional trea
tment programmes. The double treatment regimen did not significantly r
educe the overall parasite burden, as measured by faecal egg counts, b
ut did control the parasites to a level similar to that achieved by tr
aditional programmes averaging 3.7 treatments per year. The cows' eosi
nophil counts and serum liver enzyme activities were significantly low
er than in animals treated by the traditional programmes. The use of n
iclosamide in addition to the triclabendazole treatments gave no clear
advantage, although there was a significant reduction in the number o
f intermediate host snails after the application of the molluscicide.