BENZYL CATION INITIATED INTRAMOLECULAR CYCLIZATIONS - SYNTHESIS OF 1-AZABICYCLO[3.2.1]OCTENE DERIVATIVES

Authors
CSUZDI E PALLAGI I SZIRAKI I SOLYOM S
Citation
E. Csuzdi et al., BENZYL CATION INITIATED INTRAMOLECULAR CYCLIZATIONS - SYNTHESIS OF 1-AZABICYCLO[3.2.1]OCTENE DERIVATIVES, Journal fur praktische Chemie, Chemiker-Zeitung, 340(5), 1998, pp. 472-475
Citations number
12
Categorie Soggetti
Chemistry,"Chemistry Applied
Journal title
Journal fur praktische Chemie, Chemiker-Zeitung → ACNP
ISSN journal
09411216
Volume
340
Issue
5
Year of publication
1998
Pages
472 - 475
Database
ISI
SICI code
0941-1216(1998)340:5<472:BCIIC->2.0.ZU;2-J
Abstract
Benzyl cation inititiated intramolecular cyclization reactions with co njugated C-C double bonds were performed providing rac. endo-exo isome rs of 1-azabicyclo[3.2.1] octenes (2 and 3). Formation of the endo iso mer 2 is favoured. Compounds 2 possess dopamine uptake inhibitory effe ct with an additional selective MAO-B enzyme inhibitory potential. The remarkable in vitro effects do not correspond to in viva antidepressa nt activity.