ASSIGNMENT OF HUMAN BETA-GALACTOSIDASE-A GENE TO 3P21.33 BY FLUORESCENCE IN-SITU HYBRIDIZATION

Authors
TAKANO T YAMANOUCHI Y
Citation
T. Takano et Y. Yamanouchi, ASSIGNMENT OF HUMAN BETA-GALACTOSIDASE-A GENE TO 3P21.33 BY FLUORESCENCE IN-SITU HYBRIDIZATION, Human genetics, 92(4), 1993, pp. 403-404
Citations number
8
Categorie Soggetti
Genetics & Heredity
Journal title
Human genetics → ACNP
ISSN journal
03406717
Volume
92
Issue
4
Year of publication
1993
Pages
403 - 404
Database
ISI
SICI code
0340-6717(1993)92:4<403:AOHBGT>2.0.ZU;2-T
Abstract
GM1 gangliosidosis and Morquio syndrome type B (MPS IVB) are inherited lyosomal storage disorders associated with deficiency of beta-galacto sidase-A (beta GAL(A)) activity. A recombinant plasmid containing a bi otinylated cDNA (2.4-kb insert) encoding human beta GAL(A) was used to localize the enzyme locus by fluorescence in situ hybridization (FISH ). The human beta GAL(A) gene was assigned to 3p21.33 by FISH.