PERIPHERAL-BLOOD CD34(+) CELL COUNT RELIABLY PREDICTS AUTOGRAFT YIELD

A reliable measure to predict peripheral blood progenitor cell (PBPC) autograft CD34(+) cell content is required to optimize the timing of P BPC collection. We prospectively examined the peripheral blood (PB) CD 34(+) cell count in 59 consecutive patients with various malignancies and analyzed the correlation between the PB CD34(+) cell count and var ious parameters in the PBPC: autograft, Two hundred and thirty-five co llections were performed with a median of 4.0 collections per patient (range, 2-10). The median PB CD34(+) cell count at the time of collect ion was 39 x 10(6)/l (range, 0.0-285.6), The PBPC autograft parameters measured a ere the CD34(+) cell, colony-forming unit granulocyte-macr ophage (CFU-GM) and mononuclear cell (MNC) content. There was a strong linear correlation between PB CD34(+) cells/l and autograft CD34(+) c ells/kg (I = 0.8477), The correlation with CFU-GM/kg (r = 0.5512) was weaker. There was no correlation between autograft CD34(+) cells/kg an d PB WBC (I = 0.0684), PB MNC (r = 0.1518) or PIE platelet count (r = 0.2010), At our institution we aim to obtain a minimum of 0.5 x 10(6) CD34(+) cells/kg with each day of collection. We demonstrate that such a collection call be reliably obtained if the PB CD34(+) cell count e xceeds 5.0 x 10(6)/l.