DETERMINATION OF URINE SATURATION WITH COMPUTER-PROGRAM EQUIL2 AS A METHOD FOR ESTIMATION OF THE RISK OF UROLITHIASIS

To investigate the risk for the development of urolithiasis in 30 chil dren with urolithiasis, 36 children with isolated hematuria, and 15 he althy control children, 24-h urinary excretion of calcium, sodium, oxa late, citrate, sulfate, phosphate, magnesium, urate, chloride, ammoniu m, and glycosaminoglycans was determined and urine saturation for calc ium oxalate was calculated with the computer program EQUIL 2. Compared with controls, children with urolithiasis had significantly increased calcium excretion, oxalate excretion, and urine saturation, whereas c hildren with isolated hematuria had significantly increased calcium ex cretion only. The best estimation of the relative risk of urolithiasis can be made after urine saturation, using logistic regression. The pe rcentage of patients correctly classified after urine saturation is 85 .41% in comparison with 80.95% and 73.81% when the estimation was done by calcium excretion and oxalate excretion, respectively. Using the b reakpoint value of 4.29 for urine saturation, it was possible to separ ate children with increased risk of urolithiasis development from the group of children with isolated hematuria.