De. Roskell et al., TREATED BACTERIAL-ENDOCARDITIS AS A HISTOLOGICAL MIMIC OF FUNGAL INFECTION, Journal of Clinical Pathology, 51(7), 1998, pp. 539-540
Histological assessment of cardiac valve tissue contributes to the dia
gnosis of infective endocarditis and is of particular importance in ca
ses in which no organism is cultured. Antibiotic treatment of bacteria
l endocarditis may lead to abnormal bacterial morphology and staining
characteristics. Although in many cases the presence of some residual
bacteria of normal appearance makes the diagnosis straightforward, in
some only abnormal bacteria may be seen. Unless the appearances of the
se are interpreted with caution, the presence of larger spherical orga
nisms with the staining properties of a yeast may lead to an erroneous
diagnosis of fungal infection.