THE NON-NMDA GLUTAMATE-RECEPTOR ANTAGONIST GYKI-52466 COUNTERACTS LOCOMOTOR STIMULATION AND ANTICATALEPTIC ACTIVITY-INDUCED BY THE NMDA ANTAGONIST DIZOCILPINE

The effects of the non-NMDA glutamate receptor antagonist GYKI 52466 ( 2.4 and 4.8 mg/kg, i.p.) on spontaneous locomotor activity and haloper idol-induced catalepsy (0.5 mg/kg, i.p.) were assessed in naive rats a nd in rats pretreated with the NMDA antagonist dizocilpine (0.08 mg/kg , i. p.). GYKI 52466 given alone did not alter locomotor activity and haloperidol-induced catalepsy, but significantly antagonized the dizoc ilpine-induced locomotor stimulation and counteracted the anti-catalep tic effects of dizocilpine on haloperidol-induced catalepsy. Thus bloc kade of non-NMDA glutamate receptors antagonized the behavioural stimu lant effects of a NMDA receptor blockade.