DRUG-THERAPY - DOSE-RESPONSE RELATIONSHIP OF ORAL MESALAZINE IN INFLAMMATORY BOWEL-DISEASE

MESALAZINE is widely used in the treatment of inflammatory bowel disea se. Little is known about the dose-response relationship and about pos sible dose related side effects, In ulcerative colitis higher dosages of mesalazine (3 g) are more effective in maintaining a remission than lower dosages (1.5 g). In mild to moderately active ulcerative coliti s, studies also indicate that higher dosages might be more effective i n inducing remission. Dose-comparing studies in Crohn's disease are ev en more sparse, but the available results indicate higher efficacy at higher dose levels. None of the known side effects of mesalazine are c learly dose-related. A pH-dependent release system, however, can cause a sudden release of high doses of mesalazine, Consequent peak levels in serum have been implicated in mesalazine induced nephrotoxicity, Ln conclusion, despite the current practice of using increasing dosages of mesalazine in inflammatory bowel disease, both efficacy and safety have been established tentatively.