SYNTHESIS AND ANTIOXIDANT ACTIVITY OF NOVEL AMPHIPATHIC DERIVATIVES OF TEA POLYPHENOL

Authors
TANAKA T KUSANO R KOUNO I
Citation
T. Tanaka et al., SYNTHESIS AND ANTIOXIDANT ACTIVITY OF NOVEL AMPHIPATHIC DERIVATIVES OF TEA POLYPHENOL, Bioorganic & medicinal chemistry letters, 8(14), 1998, pp. 1801-1806
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
14
Year of publication
1998
Pages
1801 - 1806
Database
ISI
SICI code
0960-894X(1998)8:14<1801:SAAAON>2.0.ZU;2-#
Abstract
Hydrophobic derivatives of a tea polyphenol have been synthesized. 6, 8-Bis(octylthiomethyl)-epigallocatechin 3-O-gallate, 6, 8-bis(octylthi omethyl) -4 beta-(2-hydroxyethio)epigallocatechin 3-O-gallate and epig allocatechin 3-O-[4-O-(N-octadecylcarbamoyl)gallate] show-ed strong in hibition activity against lipid peroxidation of liposome caused by bot h lipid-soluble and water-soluble radical generators. (C) 1998 Elsevie r Science Ltd. All rights reserved.