MODELING, SYNTHESIS AND BIOLOGICAL-ACTIVITY OF NOVEL ANTIFUNGAL AGENTS (1)

Authors
TSUKUDA T SHIRATORI Y WATANABE M ONTSUKA H HATTORI K SHIRAI M SHIMMA N
Citation
T. Tsukuda et al., MODELING, SYNTHESIS AND BIOLOGICAL-ACTIVITY OF NOVEL ANTIFUNGAL AGENTS (1), Bioorganic & medicinal chemistry letters, 8(14), 1998, pp. 1819-1824
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
14
Year of publication
1998
Pages
1819 - 1824
Database
ISI
SICI code
0960-894X(1998)8:14<1819:MSABON>2.0.ZU;2-B
Abstract
The medicinal need for safe and effective systemic antifungal agents h as been intensified due to rapid growth of the immunocompromised patie nt population.(1) Although azole antifungal agents, such as fluconazol e, are most widely used today, they still have problems in efficacy (e specially against Asp. fumigatus), resistance etc.(1) Thus, we tried t o develop a new class of lanosterol C14-demethylase inhibitor which do se not have a (phenethyl)triazole moiety (.Fig,I) found in all azole a ntifungals on the market, based on the structure of restricticin 1.