A POTENT AND SELECTIVE-INHIBITION OF PARAINFLUENZA 1 (SENDAI) VIRUS BY NEW 6-OXIRANYLURACILS, 6-METHYLOXIRANYLURACILS, AND 4(3H)-PYRIMIDINONE DERIVATIVES

Authors
SALADINO R DANTI MC MINCIONE E CRESTINI C PALAMARA AT SAVINI P MARINI S BOTTA M
Citation
R. Saladino et al., A POTENT AND SELECTIVE-INHIBITION OF PARAINFLUENZA 1 (SENDAI) VIRUS BY NEW 6-OXIRANYLURACILS, 6-METHYLOXIRANYLURACILS, AND 4(3H)-PYRIMIDINONE DERIVATIVES, Bioorganic & medicinal chemistry letters, 8(14), 1998, pp. 1833-1838
Citations number
30
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
14
Year of publication
1998
Pages
1833 - 1838
Database
ISI
SICI code
0960-894X(1998)8:14<1833:APASOP>2.0.ZU;2-C
Abstract
Several new 6-oxiranyl-, 6-methyloxiranyluracils, and pyrimidinone der ivatives, synthesized by the lithiation-alkylation sequence of 1,3,6-t rimethyluracil, 1,3-dimethyl-6-chloromethyluracil, and 2-alkoxy-6methy l-4(3H)-pyrimidinones, showed a potent and selective antiviral activit y against the parainfluenza 1(Sendai) virus replication, (C) 1998 Else vier Science Ltd. All rights reserved.