SERINE DERIVED NK1 ANTAGONISTS 1 - THE EFFECT OF MODIFICATIONS TO THESERINE SUBSTITUENTS

Authors
ELLIOTT JM CASCIERI MA CHICCHI G DAVIES S KELLEHER FJ KURTZ M LADDUWAHETTY T LEWIS RT MACLEOD AM MERCHANT KJ SADOWSKI S STEVENSON GI
Citation
Jm. Elliott et al., SERINE DERIVED NK1 ANTAGONISTS 1 - THE EFFECT OF MODIFICATIONS TO THESERINE SUBSTITUENTS, Bioorganic & medicinal chemistry letters, 8(14), 1998, pp. 1845-1850
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
14
Year of publication
1998
Pages
1845 - 1850
Database
ISI
SICI code
0960-894X(1998)8:14<1845:SDNA1->2.0.ZU;2-J
Abstract
A series of novel serine derived NK, antagonists is described. The eff ect of variations in the N-benzyl, O-benzyl and serine groups are used to define the elements which are necessary for binding. (C) 1998 Else vier Science Ltd. All rights reserved.