A MEMBRANE-PERMEANT, BIOACTIVATABLE DERIVATIVE OF INS(1,3,4)P-3 AND ITS EFFECT ON CL--SECRETION FROM T-84 CELLS

Authors
RUDOLF MT TRAYNORKAPLAN AE SCHULTZ C
Citation
Mt. Rudolf et al., A MEMBRANE-PERMEANT, BIOACTIVATABLE DERIVATIVE OF INS(1,3,4)P-3 AND ITS EFFECT ON CL--SECRETION FROM T-84 CELLS, Bioorganic & medicinal chemistry letters, 8(14), 1998, pp. 1857-1860
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
14
Year of publication
1998
Pages
1857 - 1860
Database
ISI
SICI code
0960-894X(1998)8:14<1857:AMBDOI>2.0.ZU;2-2
Abstract
The synthesis of rac-2,5,6-tri-O-butyryl myo-inositol 1,3,4-trisphosph ate hexakis(acetoxymethyl) ester [Bt(3)-Ins(1,3,4)P-3/AM, 1], a membra ne-permeant derivative of myo-inositol 1,3,4-trisphosphate [Ins(1,3,4) P-3] is reported. 1 inhibited calcium-mediated chloride secretion of T -84 cells, suggesting a regulatory link of Ins(1,3,4)P3 and the biosyn thesis of the known inhibitor inyo-inositol 3,4,5,6-tetrakisphosphate. (C) 1998 Elsevier Science Ltd. All rights reserved.