SAR STUDIES OF DIARYLTRIAZOLES AGAINST BACTERIAL 2-COMPONENT REGULATORY SYSTEMS AND THEIR ANTIBACTERIAL ACTIVITIES

Authors
SUI ZH GUAN JH HLASTA DJ MACIELAG MJ FOLENO BD GOLDSCHMIDT RM LOELOFF MJ WEBB GC BARRETT JF
Citation
Zh. Sui et al., SAR STUDIES OF DIARYLTRIAZOLES AGAINST BACTERIAL 2-COMPONENT REGULATORY SYSTEMS AND THEIR ANTIBACTERIAL ACTIVITIES, Bioorganic & medicinal chemistry letters, 8(14), 1998, pp. 1929-1934
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
14
Year of publication
1998
Pages
1929 - 1934
Database
ISI
SICI code
0960-894X(1998)8:14<1929:SSODAB>2.0.ZU;2-V
Abstract
A series of diaryltriazole analogs was discovered to inhibit bacterial two-component regulatory systems in our primary assays, KinA/Spo0F an d NRII/NRI. They also showed inhibitory activity in whole cell mechani sm-based assays, and they possessed potent activities against several strains of Gram-positive pathogenic bacteria in the standard MIC broth assay. (C) 1998 Elsevier Science Ltd. All rights reserved.