N-TERMINAL PROCESSING - THE METHIONINE AMINOPEPTIDASE AND N-ALPHA-ACETYL TRANSFERASE FAMILIES

Authors
BRADSHAW RA BRICKEY WW WALKER KW
Citation
Ra. Bradshaw et al., N-TERMINAL PROCESSING - THE METHIONINE AMINOPEPTIDASE AND N-ALPHA-ACETYL TRANSFERASE FAMILIES, Trends in biochemical sciences, 23(7), 1998, pp. 263-267
Citations number
52
Categorie Soggetti
Biology
Journal title
Trends in biochemical sciences → ACNP
ISSN journal
09680004
Volume
23
Issue
7
Year of publication
1998
Pages
263 - 267
Database
ISI
SICI code
0968-0004(1998)23:7<263:NP-TMA>2.0.ZU;2-1
Abstract
Removal of the initiator methionine and/or acetylation of the alpha-am ino group are among the earliest possible chemical modifications that occur during protein synthesis in eukaryotes. These events are catalyz ed by methionine aminopeptidase and N-alpha-acetyltransferase respecti vely. Recent advances in the isolation and characterization of these e nzymes indicate that they exist as isoforms that vary in cellullar loc ation, function, and evolutionary origins.