PROBIOTICS AND ESCHERICHIA-COLI INFECTIONS IN MAN

After oral administration of live oral vaccines COLINFANT and MUTAFLOR prepared from non-enteropathogenic E.coli strains, both strains colon ized effectively the intestine in full-term and preterm infants and re mained for many weeks showing, that they were capable to establish the mself as a resident strain in the infant's gut, The presence of E,coli stimulated significantly antibody production in gut, saliva and serum of colonized infants. An early induction of secretory IgA production is important particularly in formula-fed infants, where it partly repl aces the lacking immunoglobulin supplied with mother milk. In full-ter m and premature infants the early presence of non-pathogenic E.coli st rains in the intestine decreased significantly the presence of pathoge nic bacterial strains in the intestine but also other mucosal surfaces of the body. The COLINFANT strain decreased the number of nosocomial infections, mortality rate in connection with infection, and the need for antibiotics. Both strains replaced successfully pathogenic strains in carriers after treatment with antibiotics.