S. Osada et al., SYNTHESIS OF 3-SUBSTITUTED 2,3-DEHYDROPROLINES - OXIDATIVE DECARBOXYLATION OF ETHYL HYDROGEN ACETOAMIDOMALONATE DERIVATIVES, Chemistry Letters, (7), 1998, pp. 675-676
A new synthetic method for alpha,beta-dehydroamino acid derivatives ha
ve been accomplished via lead(IV) tetraacetate oxidation of ethyl hydr
ogen acetoamidomalonate derivatives in the presence of copper(II) acet
ate. Four 3-substituted 2,3-dehydroprolines have been synthesized by t
his oxidative decarboxylation.