F. Fernandezcervilla et al., EARLY MORPHOFUNCTIONAL ALTERATIONS INDUCED BY CISPLATIN IN THE COCHLEA - A QUANTITATIVE AND ELECTROCOCHLEOGRAPHIC STUDY, ORL, 55(6), 1993, pp. 337-340
The early morphological and functional alterations of the cochlea were
studied in guinea pigs treated with cisplatin, administered to two gr
oups of animals as a single dose of 4 or 10 mg/kg body weight. Morphol
ogical changes were observed by scanning electron microscopy, and func
tional alterations were investigated by electrocochleography to record
compound action potentials. Statistically significant alterations in
neurosensory stereocilia, consisting of partial or total denudation, w
ere observed only after the exprimental administration of the higher d
ose of cisplatin; these changes were consistently associated with dist
ortions in the compound action potential.