2ND MALIGNANCY FOLLOWING TREATMENT OF ACUTE LYMPHOBLASTIC-LEUKEMIA INCHILDREN

Second malignancy is one of the serious late effects among long-term s urvivors of acute lymphoblastic leukemia (ALL) in children. Of 83 newl y diagnosed pediatric ALL patients at our hospital between January 198 0 and December 1995, four patients were found to have second malignanc ies. These included MDS/AML after B-ALL, rhabdomyosarcoma after early pre-B ALL, ependymoma after B-ALL, and astrocytoma after early pre-B A LL. The mean duration from initial ALL, to second malignancy was 5.2 y ears. The possible causes of second malignancy in these patients are d iscussed in this report, along with a review of recent literature. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.