ATYPICAL STIFF-PERSON SYNDROME WITH SPINAL MRI FINDINGS, AMPHIPHYSIN AUTOANTIBODIES, AND IMMUNOSUPPRESSION

In an atypical case of stiff-person syndrome (SPS), spinal T2-weighted MRI revealed a hyperintense lesion extending from C2 to C7 that corre sponded with the clinical symptoms and signs. CSF showed lymphocytic p leocytosis and oligoclonal bands. Amphiphysin autoantibodies were dete cted In serum and CSF; however, unlike other reported cases, no malign ancy occurred during a 3-year observation period. Methylprednisolone a nd cyclophosphamide pulse therapy led to a marked reduction of symptom s.