INVESTIGATION OF FLUORIDE ELIMINATION DURING A DIALYSIS SESSION

We have conducted a study of the elimination kinetics of fluoride ions by a log linear regression analysis of plasma levels obtained during a bicarbonate hemodialysis session, with a dialyzer in polymercaprin f or six patients with chronic renal failure. Using plasma fluoride leve ls of 35 patients studied for 20 months, we have validated these kinet ics for hemodialysis with sodium bicarbonate, acetate-free biofiltrati on, hemodiafiltration with low flow rate and other dialyzers. Our resu lts show that the decrease in plasma fluoride levels is statistically significant only after the first hour, and the fall reaches approximat ely 30% after a 4 h dialysis session. We propose that post-dialysis me asurements of plasma fluoride are now not necessary if levels before d ialysis are known. (C) 1998 Elsevier Science B.V. All rights reserved.