MEASUREMENT OF POSTPRANDIAL REMNANT-LIKE PARTICLES (RLPS) FOLLOWING AFAT-LOADING TEST

To assess the usefulness of remnant-like particles (RLPs), which repre sent potentially atherogenic lipoprotein remnants, as an index of post prandial hyperlipidemia, RLPs and other lipids were measured in 19 hea lthy adults (23-44 years old) after ingestion of a test meal (fat cont ent, 32.9%). The lipoprotein derivatives, with a marked increase after fat-loading, were triglycerides, retinyl palmitate and RLPs. The reti nyl palmitate peak lagged behind the RLP and triglyceride peaks, indic ating that it may have different kinetics than RLP and triglyceride. W hile triglycerides are considered as an index of atherosclerotic risk factor, RLPs also may be a suitable index for evaluating postprandial hyperlipidemia. RLPs remained high even 8 h after fat-loading, suggest ing that the postprandial state persists for almost the whole day. Acc ordingly, it may be important to assess postprandial remnant concentra tions. (C) 1998 Elsevier Science B.V. All rights reserved.