Dl. Vesely et al., VESSEL DILATOR ENHANCES SODIUM AND WATER-EXCRETION AND HAS BENEFICIALHEMODYNAMIC-EFFECTS IN PERSONS WITH CONGESTIVE-HEART-FAILURE, Circulation, 98(4), 1998, pp. 323-329
Citations number
25
Categorie Soggetti
Peripheal Vascular Diseas",Hematology,"Cardiac & Cardiovascular System
Background-Vessel dilator, a 37-amino acid peptide hormone synthesized
in the heart, enhances urine flow 4- to 12-fold and sodium excretion
3- to 6-fold in healthy humans. The present investigation was designed
to determine whether vessel dilator might have similar beneficial eff
ects in persons with congestive heart failure (CHF). Methods and Resul
ts-Vessel dilator (100 ng/kg body weight per minute) given intravenous
ly for 60 minutes to NYHA class III CHF subjects increased urine flow
2- to 13-fold, which was still increased (P<0,001) 3 :hours after its
infusion was stopped. Vessel dilator enhanced sodium excretion 3- to 4
-fold in CHF subjects (P<0.01), which was still significantly (P<0,01)
elevated 3 hours after infusion. Vessel dilator decreased systemic va
scular resistance 24%, pulmonary vascular resistance 25%, pulmonary ca
pillary wedge pressure 33%, and central venous pressure 27% while incr
easing cardiac output 34%, cardiac index 35%, and stroke volume index
24% without significantly affecting heart rate or pulmonary artery pre
ssure in the CHF subjects. The control CHF patients did not have any c
hanges in the above parameters. Conclusions-These results indicate tha
t vessel dilator has significant beneficial diuretic, natriuretic, and
hemodynamic properties in humans with congestive heart failure.