ANALYSIS OF TRABECULAR MICROARCHITECTURE OF HUMAN ILIAC BONE USING MICROCOMPUTED TOMOGRAPHY IN PATIENTS WITH HIP ARTHROSIS WITH OR WITHOUT VERTEBRAL FRACTURE

Iliac bone samples were obtained from 50 women with osteoarthrosis of the hip (50-80 years of age) during hip surgery for total hip joint re placement. After determining the resolution and threshold for the bina ry image, the two-dimensional (2D) and three-dimensional (3D) data of the trabecular structure were obtained in these iliac bone samples usi ng microcomputed tomography (micro-CT). Conventional histomorphometry was then performed. Both 2D and 3D parameters of the trabecular struct ure were significantly correlated with the parameters of conventional histomorphometry (r = 0.63-0.86 in 2D analysis, and r = 0.60-0.77 in 3 D analysis). The patients mere classified into the non-spinal-fracture group (n = 36) and the spinal fracture group (n = 14). There was no s ignificant difference in patient age between the two groups. The param eter values of bone mass, such as 2D fractional trabecular bone area a nd 3D fractional bone volume, and the values of trabecular number (Tb, N) in terms of both 2D and 3D analyses mere significantly smaller, and those of trabecular separation (Tb,Sp) mere significantly higher in t he spinal fracture group than in the non-spinal-fracture group. Trabec ular thickness (Tb,Th) values did not significantly differ between the two groups, There was no significant difference between 2D and 3D par ameters in discriminating the spinal fracture group from the non-spina l-fracture group. However, 3D analysis demonstrated that the value of the bone surface to bone volume (BS/BV) ratio could discriminate betwe en these two groups, These data demonstrated that micro-CT can evaluat e the 3D structure of the human iliac hone, and that decreases in the parameters of the SD-structure-related bone surface density as well as decreases in trabecular bone volume are related to osteoporotic fract ure, (Bone 23:163-169; 1998) (C) 1998 by Elsevier Science Inc. All rig hts reserved.