SOLID-PHASE SYNTHESIS OF MURAMYL DIPEPTIDES ON ISOMERIC TRIALKOXYBENZYLAMINE RESINS

New isomeric trialkoxybenzylamine resins are developed coupling phthal imidomethyl-3,5-dimethoxyphenols to the Merrifield resin, followed by subsequent treatment with hydrazine. The generated benzylamine functio n allows DCC coupling with the carboxyl function of amino acids and pe ptides which are removed as amides after treatment with trifluoroaceti c acid. These new trialkoxybenzylamine resins allow expeditious synthe ses of peptide amides and glycopeptide amides as is demonstrated for m uramyl peptides and analogues.