CYTOGENETIC ANALYSIS OF A PARACHORDOMA

We report the cytogenetic and histopathological findings in a 7-year-o ld-female child with an intranasal tumor that is most consistent with a parachordoma. Karyotypic analysis of the tumor revealed clonal numer ical and str structural chromosome abnormalities. Seven cells displaye d recurrent changes: der(2)t(2:4), del(3q), and the loss of chromosome s 9, 10, 20, and 22. Four cells showed a loss of chromosome 17. To the best of our knowledge, these are the first clonal chromosome abnormal ities described in parachordoma. (C) Elsevier Science Inc., 1998.