CONSTITUTIONAL BALANCED TRANSLOCATIONS IN ALVEOLAR RHABDOMYOSARCOMA

Authors
SAVASAN S LORENZANA A WILLIAMS JA MOHAMED AN RAVINDRANATH Y ZIELENSKA M HAMRE M HAAS JE RECTOR F SAWAF H ABELLA E
Citation
S. Savasan et al., CONSTITUTIONAL BALANCED TRANSLOCATIONS IN ALVEOLAR RHABDOMYOSARCOMA, Cancer genetics and cytogenetics, 105(1), 1998, pp. 50-54
Citations number
45
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
105
Issue
1
Year of publication
1998
Pages
50 - 54
Database
ISI
SICI code
0165-4608(1998)105:1<50:CBTIAR>2.0.ZU;2-S
Abstract
Chromosomal analysis of tumor tissue from two children with alveolar r habdomyosarcoma revealed t(1;5)(q32;q31) and t(1;22)(q21:q11.2) in all metaphases examined, respectively. Peripheral blood lymphocytes carri ed the same cytogenetic abnormality as that of the tumor cells in both patients. Parental lymphocytes were karyotypically normal in the pati ent with t(1;22), indicating a de novo constitutional translocation, b ut t(1;5) was paternally inherited in the other patient. The presence of constitutional translocations in these two children might have cont ributed to the development of alveolar rhabdomyosarcoma. (C) Elsevier Science Inc., 1998.