OPTIMAL-MODE OF OPERATION FOR TEMPERATURE INDUCTION OF BACTERIOPHAGE LAMBDA-Q(-) MUTANT IN ESCHERICHIA-COLI

Authors
CHEN BY LIM HC
Citation
By. Chen et Hc. Lim, OPTIMAL-MODE OF OPERATION FOR TEMPERATURE INDUCTION OF BACTERIOPHAGE LAMBDA-Q(-) MUTANT IN ESCHERICHIA-COLI, Bioprocess engineering, 19(1), 1998, pp. 7-10
Citations number
8
Categorie Soggetti
Engineering, Chemical","Biothechnology & Applied Migrobiology
Journal title
Bioprocess engineering → ACNP
ISSN journal
0178515X
Volume
19
Issue
1
Year of publication
1998
Pages
7 - 10
Database
ISI
SICI code
0178-515X(1998)19:1<7:OOOFTI>2.0.ZU;2-8
Abstract
An epidemic model is presented to provide theoretical considerations f or temperature induction of bacteriophage lambda in Escherichia coli. Based upon model predictions for bioreactor operations, the optimal mo de for reporter-protein induction is fed-batch since augmentation of s usceptible cells enhances lambda infection in batch cultures and washo ut of infected cells decreases induction performance in CSTR operation s. Experimental results also support that batch mode of operation is b etter than CSTR.