STUDIES ON MIXING IN HORIZONTAL ROTATING TUBULAR BIOREACTOR - PART II- PREDICTION SYSTEMS FOR ADJUSTABLE-PARAMETERS OF SPIRAL FLOW MODEL

In previous investigations on mixing in a horizontal rotating tubular bioreactor (HRTB) the structured ''spiral flow'' model was developed w hich contained four adjustable parameters [1, 2]. In order to incorpor ate the mixing model in a semifundamental scale-up procedure it was ne cessary to make a relation between the adjustable model parameters and process parameters of the bioreactor expressed as dimensionless numbe rs. Mathematical equations which relate adjustable model parameters wi th dimensionless numbers were developed by non-linear and surface regr ession methods. These equations were applied to develop the prediction systems for adjustable model parameters. In total, nine systems of eq uations for the prediction of the adjustable model parameters were est ablished and examined by simulation. Three of them (SC-2, SC-6 and SC- 9) were selected as adequate to describe the mixing performance of HRT B in a wide range of process conditions.