RGDS GLYCOSYLATED PEPTIDES AS INHIBITORS OF CELL-ATTACHMENT AND PLATELET-AGGREGATION

Glycopeptides derived from the GRGDS sequence were synthesized to stud y the effect of the sugar residue on the activity of these peptides. T he peptides were tested as inhibitors of cell adhesion to fibronectin and of platelet aggregation. The sugar moiety was found to reduce the biological activity of the parent compounds except for the cyclic deri vatives P37 and P38 where the inhibition of platelet aggregation was i ncreased. Some interesting differences were observed between the pepti des bearing sugar residues with free hydroxyl groups and those with pe racetylated sugars.