ORO-6-METHYLPHENYL)-6-METHYL-3-PYRIDINECARBOXAMIDE HYDRATE - AN ANTICONVULSANT DRUG EXHIBITING SOLID-STATE ROTATIONAL DISORDER

Authors
PALMER RA PUDDLE N LISGARTEN JN
Citation
Ra. Palmer et al., ORO-6-METHYLPHENYL)-6-METHYL-3-PYRIDINECARBOXAMIDE HYDRATE - AN ANTICONVULSANT DRUG EXHIBITING SOLID-STATE ROTATIONAL DISORDER, Acta crystallographica. Section C, Crystal structure communications, 49, 1993, pp. 1777-1779
Citations number
6
Categorie Soggetti
Crystallography
Journal title
Acta crystallographica. Section C, Crystal structure communications → ACNP
ISSN journal
01082701
Volume
49
Year of publication
1993
Part
10
Pages
1777 - 1779
Database
ISI
SICI code
0108-2701(1993)49:<1777:OH-AA>2.0.ZU;2-1
Abstract
The phenyl ring, the pyridine ring and the carboxamide group are confo rmationally planar. The Cl atom and the methyl group on the phenyl rin g are statistically disordered, by 180-degrees rotation about the N(6) -C(6) linkage, with relative occupancies of 0.7061 (5) and 0.2939 (5) at the major and minor sites, respectively. Hydrogen bonds involving t he nitrogen (donor) and the oxygen (acceptor) of the carboxamide moiet y with the water oxygen, together with the hydrogen bond between the n itrogen (acceptor) of the pyridine moiety and the water oxygen structu rally stabilize the pyridine and carboxamide groups.