OXIDATIVE STRESS AND ALCOHOLIC LIVER-DISEASE

Toxic substances generated during the metabolism of alcohol in the liv er may contribute to the development of alcoholic liver disease. These substances include highly reactive molecules that can destroy vital c ell components through a process called oxidation. Cells are protected against oxidation by the action of certain enzymes, vitamins, and oth er substances, known collectively as antioxidants. An imbalance betwee n oxidants and antioxidants can lead to oxidative stress, characterize d by escalating cell damage. Evidence suggests that the major energy-g enerating structures within cells (i.e, mitochondria) may be especiall y sensitive to oxidative stress, resulting in diminished energy produc tion. Medications that reduce oxidative stress in mitochondria may ame liorate liver disease.