The progressive loss of renal function in children with chronic renal
failure (CRF) has a negative influence on their nutritional status and
statural growth. Supportive therapies with 1-25 dihydroxy-vitamin D3,
recombinant erythropoietin and growth hormone have significantly impr
oved the biochemical and clinical features but the success of these th
erapies is largely related to an appropriate diet, with adequate prote
in/caloric intakes. Children more than adults have minimal protein req
uirements to avoid malnutrition and growth impairment FAO/WHO and RDA
recommendations save as guidelines for a correct diet in children with
CRF. Following these allowances leads to a ''normoproteic'' diet, wit
h a protein intake which is often half the unrestricted one in Western
European countries, but which is still likely to be not enough to pro
tect against renal deterioration. Indeed the European Study Group for
Nutritional Treatment of CRF in children failed to show a significant
effect of diet on the mean decline of glomerular filtration rate over
two years.