THE SYNTHESIS OF (+ -)-WILFORONIDE

Authors
SCHKERYANTZ JM LULY JR COGHLAN MJ
Citation
Jm. Schkeryantz et al., THE SYNTHESIS OF (+ -)-WILFORONIDE, Synlett, (7), 1998, pp. 723-724
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
7
Year of publication
1998
Pages
723 - 724
Database
ISI
SICI code
0936-5214(1998):7<723:TSO(->2.0.ZU;2-Q
Abstract
The first synthesis of (+/-)-wilforonide has been completed in ten ste ps from commercially available starting materials. A high-yielding mon omethylation of a reactive ketone enolate, a regioselective alpha-annu lation of an unactivated alpha-substituted cyclohexanone, and a select ive hydrogenation of the resulting unsaturated keto ester were key ste ps in the synthesis.