A NEW STEREOSELECTIVE ROUTE TO (-)-OCTALACTIN-A BASED ON INTRAMOLECULAR SMI2 PROMOTED REFORMATSKY REACTION

Authors
INOUE S IWABUCHI Y IRIE H HATAKEYAMA S
Citation
S. Inoue et al., A NEW STEREOSELECTIVE ROUTE TO (-)-OCTALACTIN-A BASED ON INTRAMOLECULAR SMI2 PROMOTED REFORMATSKY REACTION, Synlett, (7), 1998, pp. 735-736
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
7
Year of publication
1998
Pages
735 - 736
Database
ISI
SICI code
0936-5214(1998):7<735:ANSRT(>2.0.ZU;2-N
Abstract
A novel stereoselective synthesis of the key left-hand fragment of (-) -octalactin A has been achieved from methyl (R)-3-hydroxy-2-methylprop ionate employing SmI2 promoted intramolecular Reformatsky reaction of a delta-(bromoacetoxy)aldehyde as a key step.