NEW SYNTHESIS OF ALKYL-4,4-DIMETHYL-5-HALOMETHYLISOXAZOLIDIN-3-ONES VIA INTRAMOLECULAR HALOCYCLIZATION OF N-ALKYL-2,2-DIMETHYL-3-BUTENOHYDROXAMIC ACIDS
Hr. Kim et al., NEW SYNTHESIS OF ALKYL-4,4-DIMETHYL-5-HALOMETHYLISOXAZOLIDIN-3-ONES VIA INTRAMOLECULAR HALOCYCLIZATION OF N-ALKYL-2,2-DIMETHYL-3-BUTENOHYDROXAMIC ACIDS, Synlett, (7), 1998, pp. 789-791
N-Alkyl-2,2-dimethyl-3-butenohydroxamic acids and their cyclic derivat
ives were halocyclized by iodine monochloride, N-bromosuccinimide, or
N-chlorosuccinimide to afford the corresponding 2-alkyl-4,4-dimethyl-5
-halomethylisoxazolidinones and 5-membered ring fused isoxazolidinones
in excellent yields.