SYNTHESIS AND BIODISTRIBUTION OF CU-64-LABELED MONOCATIONIC DIIMINEDIOXIME COPPER(II) COMPLEXES

Monocationic copper(II) complexes of three derivatives of the diimined ioxime ligand 0-dioximino-3,9-dimethyl-4,8-diazaundeca-3,8-diene were labeled with Cu-64 in high radiochemical yield, and the biodistributio n of the complexes was measured in mice. The concentration of the comp lexes in the heart was low, but the partition coefficients of the comp lexes are less than optimal for a myocardial perfusion agent. All thre e complexes are resistant to reduction by glutathione in vitro. This s uggests that more lipophilic derivatives of these compounds merit furt her investigation as possible myocardial perfusion agents. NUCL MED BI OL 25 6:531-537, 1998. (C) 1998 Elsevier Science Inc.